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189 Further, ME1 treated with the inhibitor (piperazine-1-pyrrolidine-2,5-dione) has little effect on normal rat intestinal epithelial cells but strongly suppresses human CRC cell growth by targeting ME1 NADP + -binding site and reducing the NADPH level
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IGF-1 is necessary as well as sufficient in muscle growth (anabolic) and has been shown to also be highly anti-catabolic agent as well
The researchers concluded that IGF-I promotes an average increase of 15% in muscle mass and a 14% increase in strength in muscle tissue
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